The simple and convenient synthesis and biological activity evaluation of 5-(4-chlorophenyl)-1H-tetrazole and 5-(2-chlorophenyl)-1H-tetrazole and their sulfonyl derivatives as selective COX-2 inhibitors were studied. The compounds were investigated using carrageenan-induced rat paw edema model for their in-vivo anti-inflammatory activities and in-vitro study were carried out using HRBC membrane stabilization and protein denaturation method. Among the synthesized derivative the compound 8c and 7b shows the prominent anti-inflammatory activity as compared to standard celebocoxib.
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